The combination of IL-6 release assay and IGRA may have better sensitivity on TB diagnosis, we then analyzed the combined diagnosis and the results illustrated that in 28 smears-positive PTB patients, 22 (78.6%) were positive in both the IL-6 release assay and IGRA, another 2 (7.1%) were positive in HupB assay, and one (3.6%) was positive in IGRA assay; the specificity was 89.28% and the sensitivity was 100%. This evidence concerns the gene IL6 and tuberculosis.