In addition, melanoma cell-derived sEVs can transform lipopolysaccharide (LPS) and interferon-gamma (IFN-γ) stimulated macrophages to pro-inflammatory and pro-angiogenic TAMs, which present strong differences in gene expression compared to macrophages stimulated by interleukin-14 (IL-4) + interleukin-13 (IL-13) and LPS + IFN- γ, and higher survival rates (70). The gene discussed is IL13; the disease is melanoma.