Interestingly, stromal cell sEV secreted miR-214 and miR-214–3p are found to supress fibrosis of endometriosis lesions in murine models (92, 93); miR-214–3p was significantly downregulated and its target, connective tissue growth factor, is upregulated in ectopic lesions from endometriosis patients (93). Here, CCN2 is linked to endometriosis.