Previous studies have reported that factors such as PD‐L1 expression, neutrophil‐to‐lymphocyte ratio (NLR), tumor mutational burden (TMB), and tumor‐infiltrating lymphocytes can indicate the status of the tumor immune microenvironment and act as predictive biomarkers of ICI response.25, 26, 27, 28, 29. The gene discussed is CD274; the disease is neoplasm.