Eight AFF patients (NS2‐9) without a clinical suspicion of a monogenic bone disorder carried one or more heterozygous VUS with a CADD score ≥ 20 in P4HB, PHEX, TNFRSF11A, CREB3L1, TCIRG1, SERPINH1, LEPRE1, and PLOD2 (Table 4). The gene discussed is TNFRSF11A; the disease is bone disorder.