These encompass two different single‐base‐pair deletions in PLS3 in 2 patients (S1 and S2) diagnosed with X‐linked osteoporosis, loss‐of‐function variants in ALPL in 2 patients (S3 and S5) diagnosed with HPP, and a nonsense variant located in the C‐propeptide‐encoding region of COL1A2 in a patient (S4) diagnosed with Ehlers‐Danlos syndrome (EDS) arthrochalasia type (Table 3). The gene discussed is PLS3; the disease is Ehlers-Danlos syndrome.