FH and renal cell carcinoma: Due to the negative expression of fumarate hydratase (FH) protein in a renal tumor that was morphologically similar to fumarate hydratase-deficient renal cell carcinoma (FH-deficient RCC), corresponding molecular pathological tests were performed, and the results showed an FHp.R233H (arginine > histidine) germline mutation (inactivation mutation).