SMAD2 and colorectal carcinoma: This is clear from the fact that high miRNA-93 expression levels are linked to both low DAB2 levels and poor patient survival. Similarly, CTBP1-AS2 was shown to promote proliferation and invasion of CRC cells in vitro and in vivo by sponging miRNA-93-5p and activating the TGF-/SMAD2/3 pathway [40].