Specifically, 51 cells had higher expression of transcription factors FOS and JUN, suggesting a stress response, and 310 cells can be assumed to respond to hypoxic conditions in the tumor based on the higher expression of NDRG1 and EGLN3, which are both regulated by oxygen levels [37, 38]: NDRG1 regulates stress response and p53-mediated caspase activation [37] and EGLN3 has an important role in regulation of hypoxia-inducible factor 1 alpha (HIF1α) through prolyl hydroxylation [38]. Here, FOS is linked to neoplasm.