MAPT and Alzheimer disease: While primary defects in oxidative phosphorylation are not thought to be likely causes of AD, and mitochondrial dysfunction is in fact thought to be the result of A\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\beta$$\end{document}β and tau protein accumulation [44], these changes in expression of oxidative phosphorylation genes likely play an important role in the pathophysiology of AD [45].