A large number of previous studies have shown that the pathogenesis and progression of IC/BPS are related to immunity, and the activation and degranulation of mast cells can promote the secretion of inflammatory factors such as interleukin-6 and TNF-α, which in turn promote the inflammatory response of IC/BPS [21–23]. The gene discussed is IL6; the disease is Bartsocas-Papas syndrome 1.