Interestingly, the mRNA level of CHST11 was notably decreased in DLBCL cells (Fig. 4J), whereas the expression of USP31 and DIRAS1 was not remarkably distinct between DLBCL cells and normal B cells (Additional file 4: Fig. S3D, E), indicating that CHST11 may contribute most to the regulation of DLBCL progression. This evidence concerns the gene DIRAS1 and diffuse large B-cell lymphoma.