The expression of antiapoptotic protein Bcl-2 was increased while expression levels of proapoptotic proteins, including Cleaved-Caspase 3, Cleaved-Caspase 8, Cleaved-Caspase 9 and Cleaved-PARP, were decreased in DLBCL cells overexpressing KIAA1429 (Fig. 2M). Here, CASP8 is linked to diffuse large B-cell lymphoma.