PLP1 and Cognitive impairment: In addition, we observed some downregulated genes (such as MPZ, GJB1, CDH15, KCNQ3, and PLP1) in K-NSC cells, and abnormal expression of these genes has been reported to cause cognitive impairment, epilepsy, spasticity, and myelin abnormalities, which are similar to the disease symptoms of GLD [33–36].