IGHE and asthma: Among the patients for whom long-term follow-up data of asthma severity were available, 32 elevated IgE AA patients with total IgE levels 150–535 IU/mL (951 visits) and 33 elevated IgE AA patients with total IgE levels > 535 IU/mL (1154 visits) showed stable patterns or annual improvement of asthma severity over their 10-year follow-ups (Fig. 2).