Higher asthma severity was more frequent in children with NA (41.02%, 8.97%, and 3.85% of those with mild persistent, moderate persistent, and severe persistent asthma) than in those with AA (38.18%, 5.45%, and 0% for patient with low IgE AA and 38.27%, 7.94%, and 0% for patient with elevated IgE AA, respectively) (two-way ANOVA, P < 0.0001) (Fig. 1A, left). The gene discussed is IGHE; the disease is asthma.