Less controlled asthma was more common in children with NA (34.15%, 4.88%, and 2.44% of those with not well controlled, not well-very poorly controlled, and very poorly controlled asthma) than in children with AA (28.13%, 3.13%, and 3.13% for patient with low IgE AA and 26.79%, 0.60%, and 1.19% for patient with elevated IgE AA, respectively) (two-way ANOVA, P < 0.0001) (Fig. 1B, left). This evidence concerns the gene IGHE and asthma.