BRCA1 and neoplasm: Mucinous tumour presentation provided somewhat greater evidence for the association against BRCA1 variant pathogenicity when the diagnosis was before age 50 years (LR: 0.11 (95% CI: 0.06–0.19), moderate evidence), compared to diagnosis at/after the age of 50 (LR: 0.21 (95% CI: 0.10–0.44), moderate evidence).