Endometrioid tumours of well-differentiated grade provided evidence against VUS pathogenicity for BRCA1 (LR: 0.12 (95% CI: 0.04–0.31), moderate evidence) and BRCA2 (LR: 0.31 (95% CI: 0.12–0.84), supporting evidence). Here, BRCA1 is linked to neoplasm.