Knockdown of BCAT1 and BCAT2 led to a downregulation of mTOR signalling (Fig. 5e and Supplementary Fig. S12B) and a decrease in cell growth (Fig. 5f and Supplementary Fig. S12C), suggesting a role of BCAT1 and BCAT2 in the BCAA-mediated stimulation of mTOR signalling in ICC cells. The gene discussed is MTOR; the disease is intrahepatic cholangiocarcinoma.