FS1 case with BAP1, or OK2 case with SMAD4 and TP53)—by case—have neutral evolutionary phylogenetic trees, regardless of their tumour stage, and clustering cancer evolutionary trees [24] confirmed the independence of these patterns in the phylogenetic tree and clinicopathological factors (Supplementary Fig. S2E and Table 1). Here, SMAD4 is linked to neoplasm.