The serum TET3 level in chronic hepatitis was significantly higher than that in controls (P < 0.0001), Fig. 1A. Considering the two major groups of cases, namely non-fibrosis (median 117.73, range 71.37–174.36 ng/mL) and fibrosis (median 648.66, range154.62–1040.71 ng/mL) subjects, the TET3 levels in fibrosis were significantly higher in non-fibrosis (P < 0.001), Fig. 1B. There was no significant difference in TET3 level between the non-fibrosis and the controls. The gene discussed is TET3; the disease is fibrosis.