Consistent with this, UCA1 was markedly upregulated in primary human epidermal keratinocytes (HEK) and immortalized human keratinocytes HaCaT stimulated with IL17 and/or tumor necrosis factor alpha (TNF-α) (Fig. 2A), which was accompanied by a psoriasis-like inflammatory response (Figure. The gene discussed is IL17A; the disease is psoriasis.