IL15 and neoplasm: Notably, compared with the IR780 + 1-MT + IL-15 + L group, the NIL-IM-Lip+L group exhibited better immune cell regulation in the TLIME, verifying that the pH/MMP2/temperature triple-sensitive immunomodulatory nanoinducer NIL-IM-Lip could accumulate in tumour tissues and be directed to the LNs.