A lipid-based nanoinducer by co-loading photothermal agent IR780 and IDO1 inhibitor 1-MT into the temperature-sensitive liposome with the modification of pH-sensitive NGR and matrix metalloproteinase 2 (MMP2) responsive interleukin (IL)-15 (NGR/IL-15-IR780/1-MT-Lip, NIL-IM-Lip) was meticulously constructed to precisely target tumour tissues and be directed to the LNs as expected. This evidence concerns the gene MMP2 and neoplasm.