RGSL1 and diabetes mellitus: Scd1 has previously shown to stimulate osteogenic differentiation,14 and to be downregulated in bone marrow stromal cells from T2-DM patients.15 Regulator of G protein signaling like 1 (Rgsl1) and Forkhead box protein F1 (Foxf1) were also downregulated in T2-DM bones and were upregulated by both PTH and ABL.