To what extent these findings are specific to DKD or can be generalized to other causes of CKD requires further analysis—as with TNFRSF1A and TNFRSF1B, many of the associations identified in Joslin and Pima studies have been corroborated by proteomic associations with eGFR decline and CKD progression among individuals without diabetes. Here, TNFRSF1B is linked to diabetic kidney disease.