Recently, we demonstrated that in adult cardiac myocytes, Ffar4-cPLA2α signaling directly and uniquely increased synthesis of 18-HEPE (34), which helps to explain the reduced levels of 18-HEPE in HDL and hearts of Ffar4KO mice both at baseline and in response to the HFpEF-MetS diet. Here, FFAR4 is linked to metabolic syndrome.