FFAR4 and metabolic syndrome: The beneficial effects of Ffar4 on metabolism and inflammation (21, 23), the high incidence of MetS in HFpEF patients (8), and the recently described cardioprotective effects of Ffar4 (34) led us to hypothesize that loss of Ffar4 would worsen ventricular remodeling in a mouse model of HFpEF secondary to MetS (HFpEF-MetS).