PGF and hypertensive disorder: Indeed the 2021 International Society for the Study of Hypertension in Pregnancy (ISSHP) [74] now includes angiogenic factors as a criterion to define uteroplacental dysfunction (placental abruption, PlGF <5th centile for gestational age or sFlt-1/PlGF ratio >38, FGR, abnormal umbilical artery Doppler waveform analysis or intrauterine fetal death).