In the present study, they demonstrate that the reduction in blood pressure in all three models of hypertension seem to share a basic mechanism adaptation to increase sodium clearance as shown by an increase in the fractional excretion of sodium (FENa) that is associated with the decrease expression of the sodium transporters NCC (sodium-chloride symporter), Nhe3 (sodium-hydrogen exchanger 3), and ENaC (epithelium sodium channel) in the A2HTN and SSHTN models of hypertension but not in the LHTN model of hypertension. Here, SLC12A3 is linked to Hypertension.