PSEN1 and Alzheimer disease: Fe2+ and Fe3+ were detected simultaneously in the cortex region and compared between 11-month-old wild-type (WT) mice and 5xFAD mice that express mutant humanized amyloid precursor protein and mutant human presenilin 1 (PSEN1) transgenes, which are commonly used as an AD model (Fig. 4A) (77).