Considering that FARSB is highly correlated with HCC immune cell infiltration, to continue to understand the contribution of FARSB in HCC immunotherapy, we revealed the relationship between FARSB and HCC immune checkpoints, and we explored that high expression of FARSB was closely associated with PD1, PD-L1, CTLA-4, CD80, B7-H3, and TIM-3. This evidence concerns the gene CD80 and hepatocellular carcinoma.