This finding indicatespossible effector similarity between CD4+ and CD8+ T-cells crucial to the etiology of CBZ hypersensitivity, which maybe an important contributor to the etiology of CBZ hypersensitivity.A recent single-cell sequencing study of CBZ-responsive CD8+ T-cells also showed a similar set of TCR Vβ clonality in CBZ-naïvehealthy individuals and SJS–TEN patients who carry HLA-B*15:02. Here, CD8A is linked to toxic epidermal necrolysis.