TP53 and squamous cell lung carcinoma: In addition, Acidovorax and Comamonas were also more abundant in tumors carrying TP53 mutations, the most common somatic mutation in lung squamous cell carcinoma and strongly associated with prognostic survival of lung squamous carcinoma patients, suggesting that Acidovorax and Comamonas are specific for lung SCC with TP53 mutations (26, 44, 45).