We speculate that the association between MEG3 and Comamonadaceae in lung squamous carcinoma patients might be able to be described by TP53: in NSCLC patients with deletion of MEG3 expression and relative increase in Comamonadaceae due to mutations in the TP53 locus, there is a negative correlation between MEG3 expression and Comamonadaceae abundance, in agreement with our findings in host gene-tissue microbial association analysis in Fig. 3D. Here, MEG3 is linked to non-small cell lung carcinoma.