A striking example of a T2T strategy in JIA is the Best 4 Kids study, comparing three treatment arms (DMARD only, MTX combined with corticosteroids, and MTX combined with anti TNF) but also allowing early “crossover” to the combination arm of MTX combined with anti-TNF when the treatment target at time point three months was not met [94]. Here, TNF is linked to juvenile idiopathic arthritis.