For JIA, epigenetic analysis of specific histone marks (H3K27ac) showed that synovial fluid derived CD4+ T cells and monocytes display a disease-specific signature of both enhancers and super-enhancers, non-coding regulatory elements in cis-acting DNA sequences of several hundreds to up to 50 000 (50 kb) base pairs in size, to which transcription factors and cofactors can bind and control transcription. This evidence concerns the gene CD4 and juvenile idiopathic arthritis.