EIF2AK2 and type 2 diabetes mellitus: On this note, Zu et al. recently showed that metformin, an FDA-approved drug widely used for treating type 2 diabetes, inhibits PKR activation, reduces DPR proteins RAN translated from the sense strand, and improves behavioral and pathological deficits in BAC transgenic mice expressing G4C2 repeats (Zu et al., 2020).