[52] found that adipocyte‐derived exosome miR‐27a reduced the expression of IRS‐1 and glucose transporter protein GLUT4 in skeletal muscle cells by targeting PPARγ, suggesting that adipose tissue‐derived miR‐27a may play a vital role in the development of obesity‐induced IR in skeletal muscle. This evidence concerns the gene IRS1 and obesity due to melanocortin 4 receptor deficiency.