Perhaps, the proposed link between impaired muscle strength with incidence of dementia may in part be mediated by vascular‐related mechanisms (and environment/lifestyle), rather than primarily genetic variants (e.g. Apolipoprotein E Ɛ4; APOEƐ4) that are commonly associated with AD,9 a greater cause of death for women than men after 80 years.13 The gene discussed is APOE; the disease is Alzheimer disease.