NLRP3 and infection: The differential kinetics between PFO and lecithinase in activating NLRP3 may be due to delayed or reduced production of lecithinase relative to PFO during the early phase of the infection, which is supported by studies showing that the JIR325 strain, a toxinotype A C. perfringens, used in our study has relatively low lecithinase production (Bullifent et al, 1996; Keyburn et al, 2006).