We obtained data for one or two of the top five important TFs in each cell type: NFKB1 in macrophages (Somma et al, 2021), IRF8 in AML (Liss et al, 2021) and IRF1 and IRF2 in T‐cells (Freimer et al, 2022). The gene discussed is IRF1; the disease is acute myeloid leukemia.