Long-term OSA was linked with elevated levels of circulating markers of inflammation, including C-reactive protein (CRP), intercellular adhesion molecule-1 (ICAM-1), interleukin-8 (IL-8), and monocyte chemoattractant protein-1 (MCP-1) [28-31]. This evidence concerns the gene CXCL8 and obstructive sleep apnea syndrome.