It was reported that Caulis Spatholobi can down-regulate the PI3K-AKT signaling pathway, and hence, we speculated that induction of apoptosis of K562 cells by regulating the PI3K-AKT pathway might be one of the main mechanisms of Caulis Spatholobi in the treatment of CML. The gene discussed is AKT1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.