ATXN2 and spinocerebellar ataxia type 2: Antisense oligonucleotide drugs (ASOs) directed at the ATXN2 gene had been administered to the central nervous system of SCA2 mouse models and had a dramatic effect on survival and improved motor function of mouse with SCA2 phenotypes (Becker et al., 2017; Scoles et al., 2017).