Specific depletion of COMMD3 confirmed its potential role as a tumour suppressor (Fig. 2A), while other genes, including several known regulators (AXL, ACVR1B, and DLG2) were also potential suppressors of the invasive phenotype in T-47D cells, showing enhanced growth defined by colony size when the gene was knocked down (Fig. S2, Table 1 and Table S1). This evidence concerns the gene ACVR1B and neoplasm.