There were no significant associations with survival in either TNBC or HER2 + groups (not shown), but COMMD3 protein loss in ER + HER2-negative tumours was associated with poorer survival outcomes, particularly luminal A-like cases (defined here by Ki67 staining in ≤ 20% of tumour cells; Fig. 2H). The gene discussed is COMMD3; the disease is neoplasm.