Research on the pathogenesis of psoriasis has developed rapidly over the past 15 years, involving multiple intracellular signaling pathways (PI3K, AKT, JAK-STAT, JNK, WNT, etc.), and the IL-23/Th17 axis is now recognized as a key link in the immunopathogenesis of psoriasis. This evidence concerns the gene MAPK8 and psoriasis.