Interestingly, we found that the treatment of hepatocytes for 24 h with sEVs isolated from CRC biopsy (a representative TEM image of these sEVs is reported in Fig. 7a) induced a concurrent increase in Vimentin and a decrease in CK8/18 expression, unlike sEVs isolated from the biopsy of the corresponding non-CRC mucosa (Fig. 7b). Here, KRT8 is linked to colorectal carcinoma.