Of note, inflammasome activation is not only seen in patients and models of this rare recessive autosomal mutation in PARK7. Convincing evidence now links NLRP3 activation to PD and neurodegeneration supporting microglia and BMDM activation both in various mouse models and human patient samples [123, 124, 127, 129]. The gene discussed is NLRP3; the disease is Parkinson disease.