MUC5AC and serum lipopolysaccharide activity: Some studies found that Akkermansia was significantly increased in T2D patients in fecal flora analysis, and it was speculated that Akkermansia may destroy the intestinal mucosal barrier by degrading mucin to produce H2S gas and other effects, which could intensify the occurrence of endotoxemia related to intestinal flora and nonspecific inflammatory reactions in the body [46].