Its expression shows high heterogeneity in GIST [35, 152]; about 16.3%-69.0% of GIST samples present PD-L1 expression [34, 96, 98, 103, 105, 109, 123, 124], and in the same sample, there might be less than 10% of tumor cells express PD-L1 [34]. Here, CD274 is linked to gastrointestinal stromal tumor.