LOP628-emtansine (DM1) is sensitive in tumor cells with high KIT level, regardless of its mutational status, suggesting that this ADC may be used in the treatment of KIT-mutant and KIT-WT GIST [248–250], but the hypersensitivity reactions (HSRs) caused by LOP628-DM1 may constrain its usage in clinic [250]. The gene discussed is KIT; the disease is gastrointestinal stromal tumor.