IL6 and neoplasm: On the one hand, neutrophil promotes angiogenesis and progression of tumors [79] through secreting tumor growth promoting factors, such as vascular endothelial growth factor (VEGF) [80, 81], matrix metalloproteinase [82, 83], hepatocyte growth factor (HGF) [84], interleukin 6 (IL-6) [85] and IL-8 [86].