In this study, we used the Imvigor210 dataset, a study of patients with metastatic urothelial cancer treated with anti-PD-L1 drugs, to identify genes that were different between the anti-PD-L1 treatment response group and the non-response group and intersected with the lncRNA of bladder cancer in the TCGA cohort to obtain lncRNA associated with immunotherapy. This evidence concerns the gene CD274 and urinary bladder carcinoma.