TP53 and neoplasm: According to the results of the multivariate Cox regression analysis (Fig. 8F, Table 5), TP53 mutations, cancer status, and new tumor events after initial treatment affected the prognosis (TP53-WT, HR = 0.72 [95% CI, 0.53 to 0.98], P < 0.05; new tumor event after initial treatment, P < 0.05; cancer status, P < 0.05).