YTHDF1‐3 destabilize m6A‐modified RNAs;[23, 24] of these, YTHDF2 is a major degradation‐inducing reader protein.[24] For example, YTHDF2 promoted liver cancer progression by promoting the degradation of suppressor of cytokine signaling 2 (SOCS2).[33] Consistent with the abovementioned studies, our data indicated that METTL3‐mediated m6A modification suppresses FOXO1 expression in a YTHDF2‐dependent manner. The gene discussed is YTHDF2; the disease is liver cancer.