First identified in chromosomal translocations found in human tumors,[31] FOXO1 was thought to play roles in the occurrence and development of several human cancers.[32] In addition, FOXO1 has also been considered to play critical roles in energy metabolism, cell proliferation and oxidative stress resistance.[21] The present study showed that FOXO1 is a key target of METTL3‐mediated m6A modification during IR‐induced EMT. The gene discussed is FOXO1; the disease is cancer.