In this study, we examined the effect of disrupting the Zn transporters ZNT5 and ZNT7 (because ZNT6 loses zinc transport activity and functions as the auxiliary subunit of ZNT5-634,35) on pigmentation in human melanoma cells and medaka fish, and provide evidence that ZNT5–6 and ZNT7 are essential for TYRP1 expression and activity. This evidence concerns the gene SLC30A5 and melanoma.