We found that both drugs don't have significant effect on fasting insulin, unlike the findings of kabadi et al., which show that glimepiride significantly reduce fasting insulin (p < 0.01)20, but this may be due to the difference in the duration of our study and their study, however, Ramirez-Rodriguez et al. found that dapagliflozin don’t have significant effect on fasting insulin or insulin secretion in prediabetic patients21, which is in accordance with our findings, but our findings are in patients with type 2 diabetes. Here, INS is linked to type 2 diabetes mellitus.