We have found that both glimepiride and dapagliflozin have significantly reduced insulin resistance as indicated by HOMA-IR, these findings are in agreements with the findings of kabadi et al. which showed that glimepiride improved insulin sensitivity significantly20, and the findings of Merovci et al. that showed that the whole-body insulin sensitivity is improved by dapagliflozin22. The gene discussed is INS; the disease is Insulin resistance.