Concomitant immunity was only partially impacted by CD4 depletion (Fig. 7b), with significantly larger tumors than mice with primary tumors and no CD4 depletion (p < 0.0001), but significantly smaller tumors than naïve mice (p < 0.01) and approximately half of the mice rejected the second tumor (Fig. 7biii). The gene discussed is CD4; the disease is neoplasm.