While the PK5L1940 pancreatic adenocarcinoma cells have a low basal level of MHCI, MHCI can be upregulated via exposure to IFN (Fig. 2c), meaning that CD8 T cells may have varying TCR activation in a microenvironmental niche according to fluxes in IFN levels. The gene discussed is IFNA1; the disease is pancreatic adenocarcinoma.