Among SIY-pentamer-binding T cells in untreated PK5L1940 pancreatic adenocarcinomas, approximately half of the CD103+ T cells express Nur77-GFP (Fig. 2bi–ii, Supplemental Fig. S3a), indicating that these Nur77-GFP+ CD103+ CD8 T cells are actively engaging antigen. This evidence concerns the gene ITGAE and pancreatic adenocarcinoma.