PDX1 and pancreatic neoplasm: To generate spontaneous pancreatic tumors in these mice, we crossbred Pdx1-Cre/R26LSL-LSIY with KrasLSL-G12D/+Tp53LSL-R172H/+ mice to generate KPC-LSIY mice as well as with Pdx1-Cre mice to generate conventional KPC mice.