PRKN and Parkinson disease: When challenging the neurons with CCCP to induce maximal respiration, both heterozygous variant carriers and the homozygous PRKN-PD line revealed a significant decrease of oxygen consumption (controls 1.18 ± 0.13 vs. 0.79 ± 0.1 vs. 0.66 ± 0.15; p = 0.044, p = 0.02, respectively) (Fig. 3d).