PRKN and Parkinson disease: This parameter was significantly reduced for the homozygous PRKN-PD line (1.26 ± 0.15 vs. 0.70 ± 0.17; p = 0.026) but also for the heterozygous PRKN variant lines (1.26 ± 0.15 vs. 0.83 ± 0.15; p = 0.049) (Fig. 3e).