Consistently, inhibition of HDAC3 has also been proved to reverse pathological tau phosphorylation at Thr181, Ser202, and Ser396, promote Aβ degradation and decrease the accumulation of Aβ1–42 protein levels in the brain and periphery, and significantly improves spatial memory in another triple transgenic AD mouse model (3xTg-AD) [140]. This evidence concerns the gene MAPT and Alzheimer disease.