In pulmonary fibrosis (PF) mice, HDAC3 combines with the profibrotic transcriptional factor forkhead box protein M1 (FOXM1) and binds to Nrf2 promoter, resulting in a decrease of local histone 3 acetylation and repression of Nrf2 and its transcription. Here, NFE2L2 is linked to pulmonary fibrosis.