Of note, the expression of SMAD7 was markedly suppressed in LAD as compared to the normal tissues (Fig. 1a, b), and high SMAD7 expression level was associated with favorite prognosis of the LAD patients in the TCGA dataset (> 60 months median survival time and 52.855% 5-year survival rate in high SMAD7 expression subgroup vs 45.3 months median survival time and 28.337% 5-year survival rate in low SMAD7 expression subgroup, P = 0.0057) (Fig. 1c). Here, SMAD7 is linked to leukocyte adhesion deficiency.